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Code
OST00112W
$240USD
ID Tag
Rb521-290608-WS
Immunogen
A synthetic peptide from the 3d extracellular loop of human TRPM2 (TRPC7, LTRPC2) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Transient receptor potential cation channel subfamily M member 2, long transient receptor potential channel 2, LTrpC2, LTrpC-2, transient receptor potential channel 7, TrpC7, estrogen-responsive element-associated gene 1 protein, EREG1, KNP3, LTRPC2, TRPC7, KNP3, NUDT9H, NUDT9L1, MGC133383
Target
The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.
FUNCTION: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress.
CATALYTIC ACTIVITY: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
FUNCTION: Nonselective, voltage-independent cation channel mediating sodium and calcium ion influx in response to oxidative stress. Extracellular calcium passes through the channel and acts from the intracellular side as a positive regulator in channel activation. Activated by ADP-ribose, nicotinamide adenine dinucleotide (NAD(+)), reactive nitrogen species and arachidonic acid. Inactivated by intracellular ATP. Confers susceptibility to cell death following oxidative stress.
CATALYTIC ACTIVITY: ADP-ribose + H2O = AMP + D-ribose 5-phosphate.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Nagamine K, et al. Genomics 54:124-131(1998).
2. Wehage E, et al. J. Biol. Chem. 277:23150-23156(2002).
2. Wehage E, et al. J. Biol. Chem. 277:23150-23156(2002).
Limitation
For research use only
Code
OST00112W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for TRPM2.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OST00112W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Rabbit antibody to TRPM2
