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Code
OST00099W
$240USD
ID Tag
Sh74-290608-WS
Immunogen
A synthetic peptide from the 4th cytoplasmic loop of rabbit TRPV5 conjugated to an immunogenic carrier protein was used as the immunogen.
The location of the epitope is highlighted in green.
The location of the epitope is highlighted in green.
Accession
Also known
TrpV5, osm-9-like TRP channel 3, OTRPC3, Epithelial calcium channel 1, ECaC, ECaC1, Calcium transport protein 2, CaT2, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5
Target
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.
TISSUE SPECIFICITY: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.
TISSUE SPECIFICITY: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Hoenderop J.G.J, et al. J. Biol. Chem. 274:8375-8378(1999).
2. Nilius B, et al. J. Biol. Chem. 276:1020-1025(2001).
3. Hoenderop J.G, et al. EMBO J. 22:776-785(2003).
2. Nilius B, et al. J. Biol. Chem. 276:1020-1025(2001).
3. Hoenderop J.G, et al. EMBO J. 22:776-785(2003).
Limitation
For research use only
Code
OST00099W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
Sheep
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user.
Specificity
Specific for TRPV5.
Spcs X-react.
Rabbit. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OST00099W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Sheep antibody to TRPV5
