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Code
OST00088G
$260USD    Buy Now 

ID Tag
Rb0766-140209-G

Immunogen
A synthetic peptide from human TRPV1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in guinea pig.

Accession

Also known
TrpV1, osm-9-like TRP channel 1, OTRPC1, vanilloid receptor 1, capsaicin receptor, VR1, transient receptor potential cation channel subfamily V member 1

Target
Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo.
FUNCTION: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL.
Responses evoked by low pH and heat, and capsaicin can be antagonized by capsazepine.

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Hayes P, et al. Pain 88:205-215(2000).

Limitation
For research use only

Related
products
 
Code Product Name
OST00087W Rabbit antibody to TRPV1
 

Code
OST00088G
$260USD    Buy Now 

Unit size
500 ug

Conjugate
Unconjugated antibody

Host
NZ white rabbit

Purity
IgG

Clonality
Polyclonal

Isotype
Polyclonal, IgG

Applications
IHC, WB. A concentration of 10-50 ug/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Specificity
Specific for TRPV1.

Spcs X-react.
Human, guinea pig. Other species not yet tested.

Format
Lyophilised

Reconstitution
Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material.

Code
OST00087P
$120USD   

ID Tag
GS 62580-12

Unit size
50 µg

Accession

Also known
TrpV1, osm-9-like TRP channel 1, OTRPC1, vanilloid receptor 1, capsaicin receptor, VR1

Target
This is the immunising peptide for the product Rabbit antibody to TRPV1 (OST00087W)

Purity
>80%

Applications
Control peptide

Format
Lyophilised

Reconstitution
This peptide is soluble in PBS and water.

Storage
Maintain refrigerated at 2-8°C for up to 12 months. After reconstitution keep at -20°C. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

Limitation
For research use only

Related Products
OST00087W

⚬ Products
Rabbit antibody to TRPV1
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
....G6 Lysing Buffer
Content

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