DRAM antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS
IMAGES

Code

OSD00006W

$240USD

ID Tag

Rb444-150608-WS

Immunogen

A synthetic peptide from aa region 160-210 of human DRAM conjugated to blue carrier protein has been used as the antigen. The antigen shares 85% identity with mouse's and rat's.

Accession

DRAM_HUMAN
DRAM_RAT
DRAM_MOUSE

Also known

Damage-regulated autophagy modulator

Target

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.
FUNCTION: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy.
SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane protein.
INDUCTION: By p53/TP53 and p73/TP73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Ota T, et al. Nat. Genet. 36:40-45(2004).
2. Crighton D, et al. Cell 126:121-134(2006).

Limitation

For research use only

Related
products

Code	Product Name
OSD00007G	Rabbit antibody to DRAM

Code

OSD00006W

$240USD

Unit size

150 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. Use at a dilution of 1 : 200 to 1 : 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for DRAM.

Spcs X-react.

Human, rat, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.

Code

GSD00001P

$120USD

ID Tag

50278-63

Unit size

50 Âµg

Accession

DRAM_HUMAN

Also known

Damage-regulated autophagy modulator

Target

This is the immunising peptide for the product Rabbit antibody to DRAM (OSD00006W) and Rabbit antibody to DRAM (OSD00007G)

Purity

>93%

Applications

Control peptide

Format

Lyophilised

Reconstitution

This peptide is soluble in PBS and water.

Storage

Maintain refrigerated at 2-8°C for up to 12 months. After reconstitution keep at -20°C. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

Limitation

For research use only