Contactin1 antibody, Contactin 1 antibody, Contactin-1 antibody, CNTN1 antibody

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

Immunology

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Histology / Detection

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OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS
IMAGES

Code

OSC00026W

$240USD

ID Tag

Rb429-060408-WS

Immunogen

A synthetic peptide from mouse Contactin-1 (contactin 1, CNTN1) conjugated to an immunogenic carrier protein was used as the antigen.

Accession

CNTN1_MOUSE

Also known

Neural cell surface protein F3, F3cam, contactin 1, CNTN1

Target

FUNCTION: Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth.
SUBUNIT: Monomer. Interacts with CNTNAP1 in cis form. Binds to the carbonic-anhydrase like domain of protein-tyrosine phosphatase zeta. Interacts with NOTCH1 and TNR.
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
MISCELLANEOUS: F3 shares with L1, N-CAM, MAG, and other cell adhesion molecules from nervous tissue the L2/HNK-1 carbohydrate epitope.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Gennarini G, et al. J. Cell Biol. 109:775-788(1989).
2. Hu Q.-D, et al. Cell 115:163-175(2003).

Limitation

For research use only