Cytoplasmic domain p75 antibody, cytoplasmic domain p75NTR antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSP00002W

$240USD

ID Tag

Rb309-200308-WS

Immunogen

A synthetic peptide from the cytoplasmic domain of rat p75NTR conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in mouse.

Accession

p75NTR_RAT
p75NTR_MOUSE

Also known

Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR

Target

FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Radeke M.J, et al. Nature 325:593-597(1987).
2. Metsis M, et al. Gene 121:247-254(1992).
3. Kong H, et al. J. Neurosci. 21:176-185(2001).

Limitation

For research use only

Related
products

Code	Product Name
OSP00003W	Rabbit antibody to p75NTR
OSP00004W	Sheep antibody to p75NTR

Code

OSP00002W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for p75NTR.

Spcs X-react.

Rat, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSP00002W