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Code
OSB00008W
$240USD
ID Tag
Rb417-200308-WS
Immunogen
A synthetic peptide from aa region 2-40 of mouse BEX1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.
Accession
Also known
Brain expressed gene 1, BEX1, EG2RVC; BEX2, Brain-expressed X-linked protein 2 homolog
Target
BEX1:
FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
SUBUNIT: Interacts with OMP. Interacts with neurotrophin receptor p75NTR/NGFR.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Predominantly nuclear.
TISSUE SPECIFICITY: Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve.
DEVELOPMENTAL STAGE: Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level).
BEX2:
SUBUNIT: Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states.
SUBUNIT: Interacts with OMP. Interacts with neurotrophin receptor p75NTR/NGFR.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Shuttles between the cytoplasm and the nucleus. Predominantly nuclear.
TISSUE SPECIFICITY: Expressed in the central nervous system. Expressed in Schwann cells from newborn sciatic nerve.
DEVELOPMENTAL STAGE: Oscillates during the cell cycle, being lowest at G1 and highest at S phase (at protein level).
BEX2:
SUBUNIT: Interacts with LMO2, possibly leading to regulate the transcriptional activity of a DNA-binding complex containing LMO2. Interacts with OMP.
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Feng Y, et al. Gene 329:93-101(2004).
2. Alvarez E, et al. Gene 357:18-28(2005).
2. Alvarez E, et al. Gene 357:18-28(2005).
Limitation
For research use only
Related
products
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Code
OSB00008W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for BEX1 and BEX2.
Spcs X-react.
Rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSB00008W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to BEX1 (2-40)
