ATG4D antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSA00031W

$240USD

ID Tag

Rb268-270108-WS

Immunogen

A synthetic peptide from mouse ATG4D conjugated to an immunogenic carrier protein has been used as the antigen.

Accession

ATG4D_MOUSE

Also known

Cysteine protease ATG4D, Autophagy-related protein 4 homolog D, Autophagin-4 Autophagy-related cysteine endopeptidase 4, AUT-like 4 cysteine endopeptidase, Apg4d, Autl4, APG4-D, Atg4dl, MGC31226, 9830134P12Rik

Target

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.
ENZYME REGULATION: Inhibited by N-ethylmaleimide
SUBCELLULAR LOCATION: Cytoplasm

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Marino G, et al. J. Biol. Chem. 278:3671-3678(2003).
2. Carninci P, et a. Science 309:1559-1563(2005).

Limitation

For research use only