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Code
OST00048W
$240USD
ID Tag
Sh39-060108-WS
Immunogen
A synthetic peptide fromf human TRPV5 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
TrpV5, osm-9-like TRP channel 3, OTRPC3, Epithelial calcium channel 1, ECaC, ECaC1, Calcium transport protein 2, CaT2, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5
Target
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.
TISSUE SPECIFICITY: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.
TISSUE SPECIFICITY: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Mueller D, et al. Genomics 67:48-53(2000).
2. Peng J.-B, et al. Genomics 76:99-109(2001).
3. Schoeber J.P, et al. Biochem. Soc. Trans. 35 (PT 1), 115-119 (2007).
4. Jiang Y, et al. Am. J. Physiol. Renal Physiol. 292 (2), F545-F554 (2007).
5. Vassilev P.M, et al. J. Membr. Biol. 184 (2), 113-120 (2001).
2. Peng J.-B, et al. Genomics 76:99-109(2001).
3. Schoeber J.P, et al. Biochem. Soc. Trans. 35 (PT 1), 115-119 (2007).
4. Jiang Y, et al. Am. J. Physiol. Renal Physiol. 292 (2), F545-F554 (2007).
5. Vassilev P.M, et al. J. Membr. Biol. 184 (2), 113-120 (2001).
Limitation
For research use only
Related
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Code
OST00048W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
Sheep
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for TRPV5.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Code
OST00048W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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