LC3C antibody, MAP1B LC3 C antibody, MAP1LC3C antibody, microtubule associated protein 1 light chain 3 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSM00023W

$240USD

ID Tag

Rb299-010308-WS

Immunogen

A synthetic peptide from human microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C, MAP1A/MAP1B LC3 C) conjugated to an immunogenic carrier protein has been used as the antigen.

Accession

MAP1LC3C_HUMAN

Also known

Microtubule-associated proteins 1A/1B light chain 3C, MAP1LC3C, MAP1A/MAP1B LC3 C, MAP1A/1B light chain 3 C, MAP1 light chain 3-like protein 3, Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3C

Target

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed.
FUNCTION: Probably involved in formation of autophagosomal vacuoles (autophagosomes).
SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins.
SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Gregory S.G, et al. Nature 441 (7091), 315-321(2006).
2. Tanida I, et al. J. Biol. Chem. 279 (35), 36268-36276(2004).
3. He H, et al. J. Biol. Chem. 278 (31), 29278-29287(2003).

Limitation

For research use only