Sh22-060108-WS

A synthetic peptide from aa region 610-660 of mouse TRPV5 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat.

TRPV5_RAT
TRPV5_MOUSE

Transient receptor potential cation channel subfamily V member 5, TrpV5, osm-9-like TRP channel 3, OTRPC3, Epithelial calcium channel 1, ECaC1, Calcium transporter 2, CaT2, Ecac

FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating .
SUBUNIT: Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation.
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Exclusively expressed in kidney.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Peng J.-B, et al. J. Biol. Chem. 275:28186-28194(2000).

For research use only

100 µl

Unconjugated antibody

Sheep

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 1000 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for TRPV5.

Mouse, rat. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

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