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Code
OSR00106W
$240USD
ID Tag
Rb144-281007-WS
Immunogen
A synthetic peptide from the 4th cytoplasmic loop of human MRGPRD conjugated to blue carrier protein was used as the antigen.
Accession
Also known
Mas-related G-protein coupled receptor, member D; Beta-alanine receptor, G-protein coupled receptor TGR7, MRGD
Target
FUNCTION: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin-stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: Localized at the plasma membrane but internalized into the cytoplasm after treatment with beta-alanine.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Zylka M.J, et al. Proc. Natl. Acad. Sci. U.S.A. 100:10043-10048(2003).
2. Shinohara T, et al. J. Biol. Chem. 279:23559-23564(2004).
2. Shinohara T, et al. J. Biol. Chem. 279:23559-23564(2004).
Limitation
For research use only
Code
OSR00106W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Specificity
Specific for MRGPRD.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSR00106W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to MRGPRD
