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Code
OSN00114W
$260USD
ID Tag
Rb2927-231116-WS
Immunogen
A synthetic peptide from mouse Nav1.8 conjugated to blue carrier protein was used as the antigen.
Accession
Also known
Sodium channel protein type X subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.8, Peripheral nerve sodium channel 3, hPN3, SCN10A, PN3
Target
FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Its electrophysiological properties vary depending on the type of the associated beta subunits (in vitro). Plays a role in neuropathic pain mechanisms.
Tissue specificity: Expressed in the dorsal root ganglia and sciatic nerve.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: It can be translocated to the extracellular membrane through association with S100A10.
Tissue specificity: Expressed in the dorsal root ganglia and sciatic nerve.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: It can be translocated to the extracellular membrane through association with S100A10.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Rabert D.K, et al. Pain 78:107-114(1998)
Limitation
For research use only
- Click to download the Data Sheet
⚬ Products
Rabbit antibody to Nav1.8
