Anti Myelin basic protein antibody, MBP antibody, Myelin membrane encephalitogenic protein antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
eLAB BOOK
MSDS/DS

Code

OSM00147G

$240USD

ID Tag

Rb2347-290414-G

Immunogen

A synthetic peptide from human MBP conjugated to blue carrier protein was used as the antigen.

Accession

MBP_HUMAN
MBP_RAT
MBP_MOUSE

Also known

MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein

Target

FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
SUBCELLULAR LOCATION: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note: Cytoplasmic side of myelin.
TISSUE SPECIFICITY: MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Roth H.J, et al. J. Neurosci. Res. 16:227-238(1986)
2. Li Y, et al. EMBO J. 24:2968-2979(2005)

Limitation

For research use only

Related
products

Code	Product Name
OSM00141W	Rabbit antibody to MBP

Code

OSM00147G

$240USD

Unit size

500 µg

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

IgG

Clonality

Polyclonal

Isotype

Polyclonal

Applications

IHC, WB. A dilution of 1: 1000 is recommended for IHC-P and 1:2000 for WB. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for MBP.

Spcs X-react.

Human, mouse, rat, marmoset. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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