IP3 R1 antibody, ITPR1 antibody, IP1 receptor antibody

Primary Antibodies

Peptides

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OST00427W

$240USD

ID Tag

Rb2268-271213-WS

Immunogen

A synthetic peptide from aa region 1140-1190 of human IP3 receptor isoform 1 conjugated to blue carrier protein was used as the antigen. The peptide shares 88% identity with rat and mouse sequences.

Accession

INSP3R1_HUMAN
INSP3R1_RAT
INSP3R1_MOUSE

Also known

Inositol 1,4,5-trisphosphate receptor type 3, IP3 receptor isoform 3, IP3R 3, InsP3R3, Type 3 inositol 1,4,5-trisphosphate receptor, Type 3 InsP3 receptor, ITPR3, INSP3R1

Target

FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways.
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Widely expressed.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Yamada N, et al. Biochem. J. 302:781-790(1994)

Limitation

For research use only

Related
products

Code	Product Name
OST00428W	Rabbit antibody to IP3R 1 (700-750)

Code

OST00427W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.

Specificity

Specific for INSP3R1.

Spcs X-react.

Human. Other species not yet tested but expected to work in rat and mouse.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OST00427W