Code
OSM00135W
$240USD
ID Tag
Rb2266-271213-WS
Immunogen
A synthetic peptide from aa region 2-45 of extracellular domain of human MC4R conjugated to blue carrier protein was used as the antigen. The peptide shares 89% identity with mouse sequence.
Accession
Also known
Melanocortin receptor 4, MC4-R
Target
Function: Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Subcellular location: Cell membrane; Multi-pass membrane protein.
Tissue specificity: Brain, placental, and gut tissues.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Valli-Jaakola K, et al. J. Clin. Endocrinol. Metab. 89:940-945(2004)
Limitation
For research use only
Related
products
Code
OSM00135W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Specificity
Specific for MC4R.
Spcs X-react.
Human. Other species not yet tested but expected to work in mouse.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of MQ water. Centrifuge to remove any insoluble material.