Rb2265-271213-WS

A synthetic peptide from aa region 90-140 of human MRAP2 conjugated to blue carrier protein was used as the antigen. The peptide shares 92% identity with mouse and rat sequences.

MRAP2_HUMAN
MRAP2_MOUSE
MRAP2_RAT

Melanocortin 2 receptor accessory protein 2, MC2R accessory protein 2

Function: Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R); however, additional evidences are required in vivo.
Subcellular location: Cell membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein. Note: The formation of antiparallel homo- and heterodimers suggest that N- and C-terminus can both localize in the cytoplasmic and extracellular parts, depending on the context.
Tissue specificity: Expressed in the adrenal gland and brain. Not expressed in other tissues.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Chan L.F, et al. Proc. Natl. Acad. Sci. U.S.A. 106:6146-6151(2009)

For research use only

	Code Product Name OSM00132W Rabbit antibody to MRAP2 (2-45)

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Specific for MRAP2.

Human. Other species not yet tested but expected to work in mouse and rat.

Lyophilised

Reconstitute in 100 µl of MQ water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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