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Code
OSA00251W
$240USD
ID Tag
Rb2231-201113-WS
Immunogen
A synthetic peptide from aa region 900-950 of human ABCC2 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Canalicular multispecific organic anion transporter 1, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Multidrug resistance-associated protein 2, ABCC2, CMOAT, CMOAT1, CMRP
Target
FUNCTION: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Subcellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Involvement in disease: Dubin-Johnson syndrome (DJS): Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. Note: The disease is caused by mutations affecting the gene represented in this entry.
Subcellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Involvement in disease: Dubin-Johnson syndrome (DJS): Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. Note: The disease is caused by mutations affecting the gene represented in this entry.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Taniguchi K, et al. Cancer Res. 56:4124-4129(1996)
Limitation
For research use only
Related
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Code
OSA00251W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for ABCC2.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSA00251W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to ABCC2 (MRP2; 900-950)
