ABCC2 antibody, MRP2 antibody, CMRP antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSA00251W

$240USD

ID Tag

Rb2231-201113-WS

Immunogen

A synthetic peptide from aa region 900-950 of human ABCC2 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

ABCC2_HUMAN

Also known

Canalicular multispecific organic anion transporter 1, ATP-binding cassette sub-family C member 2, Canalicular multidrug resistance protein, Multidrug resistance-associated protein 2, ABCC2, CMOAT, CMOAT1, CMRP

Target

FUNCTION: Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.
Subcellular location: Cell membrane; Multi-pass membrane protein
Tissue specificity: Found on the apical membrane of polarized cells in liver, kidney and intestine. The highest expression is found in liver.
Involvement in disease: Dubin-Johnson syndrome (DJS): Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. Note: The disease is caused by mutations affecting the gene represented in this entry.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Taniguchi K, et al. Cancer Res. 56:4124-4129(1996)

Limitation

For research use only