Rb2209-201113-WS

A synthetic peptide from aa region 320-360 of human KCNJ13 conjugated to an immunogenic carrier protein was used as the antigen. The peptide shares 95% identity with mouse and rat sequences.

KCNJ13_HUMAN
KCNJ13_RAT
KCNJ13_MOUSE

Inward rectifier potassium channel 13, Potassium channel, inwardly rectifying subfamily J member 13, Inward rectifier K(+) channel Kir7.1

FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
Tissue specificity: Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord.
Subcellular location: Membrane, Multi-pass membrane protein.
Involvement in disease: Defects in KCNJ13 are the cause of snowflake vitreoretinal degeneration (SVD). SVD is a developmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Partiseti M, et al. FEBS Lett. 434:171-176(1998)
2. Krapivinsky G, et al. Neuron 20:995-1005(1998)

For research use only

	Code Product Name OSK00009W Rabbit antibody to KCNJ13 (200-250) OSK00069W Rabbit antibody to KCNJ13 (2-50)

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for KCNJ13.

Human. Other species not yet tested but expected to work in rat and mouse.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet