KCNJ13 antibody, Kir7.1 antibody, Inward rectifier potassium channel 13 antibody

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

G Protein Signaling

Hydra Proteins

Immunology

Ion Channels & pumps

Microbiology

Neuroscience

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS
IMAGES

Code

OSK00069W

$240USD

ID Tag

Rb2208-201113-WS

Immunogen

A synthetic peptide from aa region 2-50 of human KCNJ13 conjugated to blue carrier protein was used as the antigen. The peptide shares 95% identity with mouse and rat sequences.

Accession

KCNJ13_HUMAN
KCNJ13_RAT
KCNJ13_MOUSE

Also known

Inward rectifier potassium channel 13, Potassium channel, inwardly rectifying subfamily J member 13, Inward rectifier K(+) channel Kir7.1

Target

FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium.
Tissue specificity: Predominantly expressed in small intestine. Expression is also detected in stomach, kidney, and all central nervous system regions tested with the exception of spinal cord.
Subcellular location: Membrane, Multi-pass membrane protein.
Involvement in disease: Defects in KCNJ13 are the cause of snowflake vitreoretinal degeneration (SVD). SVD is a developmental and progressive hereditary eye disorder that affects multiple tissues within the eye. Diagnostic features of SVD include fibrillar degeneration of the vitreous humor, early-onset cataract, minute crystalline deposits in the neurosensory retina, and retinal detachment.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Partiseti M, et al. FEBS Lett. 434:171-176(1998)
2. Krapivinsky G, et al. Neuron 20:995-1005(1998)

Limitation

For research use only

Related
products

Code	Product Name
OSK00009W	Rabbit antibody to KCNJ13 (200-250)
OSK00070W	Rabbit antibody to KCNJ13 (320-360)

Code

OSK00069W

$240USD

IHC-P on paraffin sections of human brain. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin.

IHC-P on paraffin sections of human breast cancer. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin.

IHC-P on paraffin sections of human kidney. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin.

IHC-P on paraffin sections of human small intestine. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin.

IHC-P on paraffin sections of human testis. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin.

⚬ Products

Rabbit antibody to KCNJ13 (2-50)