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Code
OSS00397W
$240USD    Buy Now 

ID Tag
Rb2206-201113-WS

Immunogen
A synthetic peptide from aa region 120-170 of mouse SMN1 conjugated to blue carrier protein was used as the antigen. The peptide shares 95% identity with rat sequence.

Accession

Also known
Survival motor neuron protein, Gemin 1

Target
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of Tmem41b mRNA. Required for normal motor neuron development.
Subcellular location: Cytoplasm. Nucleus gem. Cytoplasmic granule. Cytoplasm  myofibril  sarcomere Z line. Note: Under stress conditions colocalizes with Rpp20/Pop7 in punctuated cytoplasmic granules. Colocalizes with Actn at the Z-line of skeletal muscle.

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Schrank B, et al. Proc. Natl. Acad. Sci. U.S.A. 94:9920-9925(1997)

Limitation
For research use only

Related
products

⚬ Products
Rabbit antibody to SMN1 (120-170)
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
....G6 Lysing Buffer
Content

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