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Code
OSS00393W
$260USD
ID Tag
Rb2211-201113-WS
Immunogen
A synthetic peptide from aa region 150-200 of human SMN1 conjugated to blue carrier protein was used as the antigen.
Accession
Also known
Survival motor neuron protein, Gemin 1, SMN, SMNT, SMNC
Target
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. It may also play a role in the metabolism of snoRNPs. Required in motor neurons and proprioceptive neurons to ensure correct U12 intron splicing and proper levels of Tmem41b mRNA. Required for normal motor neuron development.
Subcellular location: Cytoplasm. Nucleus ⺠gem. Cytoplasmic granule. Cytoplasm ⺠myofibril ⺠sarcomere ⺠Z line. Note: Under stress conditions colocalizes with Rpp20/Pop7 in punctuated cytoplasmic granules. Colocalizes with Actn at the Z-line of skeletal muscle.
Tissue specificity: Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).
Subcellular location: Cytoplasm. Nucleus ⺠gem. Cytoplasmic granule. Cytoplasm ⺠myofibril ⺠sarcomere ⺠Z line. Note: Under stress conditions colocalizes with Rpp20/Pop7 in punctuated cytoplasmic granules. Colocalizes with Actn at the Z-line of skeletal muscle.
Tissue specificity: Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Gennarelli M, et al. Biochem. Biophys. Res. Commun. 213:342-348(1995)
Limitation
For research use only
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Code
OSS00393W
$260USD
Unit size
100 ul
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for SMN1.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSS00393W
$260USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to SMN1 (150-200)
