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Code
OSP00186W
$240USD
ID Tag
Rb2186-011013-WS
Immunogen
A synthetic peptide from aa region 520-570 of human PARIS conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Accession
Also known
Zinc finger protein 746, Parkin-interacting substrate, ZNF746
Target
FUNCTION: Transcription repressor that specifically binds to the 5'-TATTTT[T/G]-3' consensus sequence on promoters and repress transcription of PGC-1-alpha (PPARGC1A), thereby playing a role in regulation of neuron death.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus Probable. Note: Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
Tissue specificity: Widely expressed. In brain, it is heterogeneously distributed throughout the brain and localizes to neurons, including substantia nigra pars compacta dopamine-containing neurons. Weakly expressed in cerebellum and midbrain.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus Probable. Note: Mainly localizes to the cytoplasm; probably translocates to the nucleus to repress selected genes.
Tissue specificity: Widely expressed. In brain, it is heterogeneously distributed throughout the brain and localizes to neurons, including substantia nigra pars compacta dopamine-containing neurons. Weakly expressed in cerebellum and midbrain.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Shin J.H, et al. Cell 144:689-702(2011)
Limitation
For research use only
Code
OSP00186W
$240USD
Unit size
100 ul
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for PARIS.
Spcs X-react.
human, mouse. Other species not yet tested but expected to work in rat.
Format
Lyophilised
Reconstitution
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSP00186W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to PARIS (520-570)
