GW182 antibody, cytoplasm marker antibody, TNRC6 antibody, TNRC6A antibody, Protein GW1 antibody, Sjoegren syndrome, autoimmune

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

Immunology

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Peptides

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSG00097W

$240USD

ID Tag

Rb2151-011013-WS

Immunogen

A synthetic peptide from aa region 2-50 of mouse GW182 autoantigen conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human.

Accession

GW182_HUMAN
GW182_MOUSE

Also known

Trinucleotide repeat-containing gene 6A protein, CAG repeat protein 26, Glycine-tryptophan protein of 182 kDa, Protein GW1, TNRC6A, TNRC6, CAGH26, TNR6A

Target

Function: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins.
Subcellular location: Cytoplasm âº P-body. Note: Mammalian P-bodies are also known as GW bodies (GWBs).
Tissue specificity: Ubiquitous.
Involvement in disease: Antibodies against TNRC6A are found in sera from patients with Sjoegren syndrome (SS), ataxia and sensor neuropathy diseases that developed autoantibodies against protein of the GWB structure. Autoantibodies were mapped to the GW-rich mid-part, the non-GW-rich region and the C-terminus of the protein.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Eystathioy T, et al. Mol. Biol. Cell 13:1338-1351(2002)

Limitation

For research use only

Code

OSG00097W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for GW182.

Spcs X-react.

Human, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSG00097W