Telomerase reverse transcriptase antibody, TERT antibody, Transcriptase antibody

Primary Antibodies

ABC Transporters

Autophagy

Cancer

Cellular

Immunology

Reporter Genes & Tags

Reproduction

SLC & Regulators

Subcellular Markers

Toxins

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OST00412W

$240USD

ID Tag

Rb2187-011013-WS

Immunogen

A synthetic peptide from aa region 950-1000 of human TERT conjugated to an immunogenic carrier protein was used as the antigen.

Accession

TERT_HUMAN

Also known

Telomerase catalytic subunit, HEST2, Telomerase-associated protein 2, HEST2, TP2, TERT, EST2, TCS1, TRT

Target

FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBUNIT: Component of the telomerase ribonucleoprotein complex at least composed of TEP1, EST1A, POT1 and a telomerase RNA template component (TER). Interacts with PINX1 and MCRS1.
SUBCELLULAR LOCATION: Nucleus. Telomere.
DISEASE: Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Nakamura T.M, et al. Science 277:955-959(1997).
2. Meyerson M, et al. Cell 90:785-795(1997).

Limitation

For research use only