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Code
OST00412W
$240USD
ID Tag
Rb2187-011013-WS
Immunogen
A synthetic peptide from aa region 950-1000 of human TERT conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Telomerase catalytic subunit, HEST2, Telomerase-associated protein 2, HEST2, TP2, TERT, EST2, TCS1, TRT
Target
FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBUNIT: Component of the telomerase ribonucleoprotein complex at least composed of TEP1, EST1A, POT1 and a telomerase RNA template component (TER). Interacts with PINX1 and MCRS1.
SUBCELLULAR LOCATION: Nucleus. Telomere.
DISEASE: Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis.
CATALYTIC ACTIVITY: Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
SUBUNIT: Component of the telomerase ribonucleoprotein complex at least composed of TEP1, EST1A, POT1 and a telomerase RNA template component (TER). Interacts with PINX1 and MCRS1.
SUBCELLULAR LOCATION: Nucleus. Telomere.
DISEASE: Activation of telomerase has been implicated in cell immortalization and cancer cell pathogenesis.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Nakamura T.M, et al. Science 277:955-959(1997).
2. Meyerson M, et al. Cell 90:785-795(1997).
2. Meyerson M, et al. Cell 90:785-795(1997).
Limitation
For research use only
Related
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Code
OST00412W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for TERT.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OST00412W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to TERT (950-1000)
