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Code
OSC00309W
$240USD
ID Tag
Rb2134-230713-WS
Immunogen
A synthetic peptide from aa region 60-110 of mouse CNGA1 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
CNGA1, cGMP-gated cation channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel alpha-1, Cyclic nucleotide-gated channel, photoreceptor, Cyclic nucleotide-gated cation channel 1, Rod photoreceptor cGMP-gated channel subunit alpha, CNCG, CNCG1
Target
FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Rod cells in the retina.
Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Rod cells in the retina.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Pittler S.J, et al. J. Biol. Chem. 267:6257-6262(1992)
2. Karlson K.H, et al. Biochim. Biophys. Acta 1236:197-200(1995)
2. Karlson K.H, et al. Biochim. Biophys. Acta 1236:197-200(1995)
Limitation
For research use only
Related
products
products
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Code
OSC00309W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for CNGA1.
Spcs X-react.
Mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSC00309W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to CNGA1 (60-110)
