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Code
OSL00022W
$240USD    Buy Now 

ID Tag
Rb2118-230713-WS

Immunogen
A synthetic peptide from aa region 300-350 of mouse LGI1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human.

Accession

Also known
Leucine-rich glioma-inactivated protein 1, Epitempin 1, EPT

Target
FUNCTION: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
SUBCELLULAR LOCATION: Secreted. Cell junction › synapse. Note: Isoform 1 but not isoform 2 is secreted. Isoform 1 is enriched in the Golgi apparatus while isoform 2 accumulates in the endoplasmic reticulum.
TISSUE SPECIFICITY: Predominantly expressed in neural tissues, especially in brain. Expression is reduced in low-grade brain tumors and significantly reduced or absent in malignant gliomas. Isoform 1 is absent in the cerebellum and is detectable in the occipital cortex and hippocampus; higher amounts are observed in the parietal and frontal cortices, putamen, and, particularly, in the temporal neocortex, where it is 3.5 times more abundant than in the hippocampus (at protein level). Isoform 3 shows the highest expression in the occipital cortex and the lowest in the hippocampus (at protein level).

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Chernova O.B, et al. Oncogene 17:2873-2881(1998)

Limitation
For research use only

⚬ Products
Rabbit antibody to LGI1 (300-350)
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
Tissue lysate preparation
G2 Lysing Buffer
R Lysing Buffer
G3 Lysing Buffer
G4 Lysing Buffer
G5 Lysing Buffer
G6 Lysing Buffer
Content

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