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Code
OSA00222W
$240USD
ID Tag
Rb1967-091212-WS
Immunogen
A synthetic peptide from aa region 825-875 of human ABCC6 conjugated to blue carrier protein was used as the antigen.
Accession
Also known
Multidrug resistance-associated protein 6, ATP-binding cassette sub-family C member 6, Anthracycline resistance-associated protein, Multi-specific organic anion transporter E, MOAT-E, ARA, MRP6
Target
FUNCTION: May participate directly in the active transport of drugs into subcellular organelles or influence drug distribution indirectly. Transports glutathione conjugates as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS).
Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE).
Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2).
Subcellular location: Membrane; Multi-pass membrane protein. Note: Localized to the basolateral membrane.
Tissue specificity: Expressed in kidney and liver. Very low expression in other tissues.
Defects in ABCC6 are the cause of pseudoxanthoma elasticum (PXE).
Defects in ABCC6 are the cause of arterial calcification of infancy, generalized, type 2 (GACI2).
Subcellular location: Membrane; Multi-pass membrane protein. Note: Localized to the basolateral membrane.
Tissue specificity: Expressed in kidney and liver. Very low expression in other tissues.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Kool M, et al. Cancer Res. 59:175-182(1999)
2. Gheduzzi D, et al. Hum. Mutat. 24:438-439(2004)
2. Gheduzzi D, et al. Hum. Mutat. 24:438-439(2004)
Limitation
For research use only
Code
OSA00222W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for ABCC6.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSA00222W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
Code
OSA00222W
$240USD
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IHC on paraffin sections of human stomach tissue using Rabbit antibody to ABCC6 (825-875) OSA00222W. HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions. Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin. |
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IHC on paraffin sections of human large intestine tissue using Rabbit antibody to ABCC6 (825-875) OSA00222W. HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions. Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin. |
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IHC on paraffin sections of human stomach tissue using Rabbit antibody to ABCC6 (825-875) OSA00222W. HIER: 1 mM EDTA, pH 8 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturer's instructions. Primary antibody: dilution 1: 1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin. |
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Rabbit antibody to ABCC6 (825-875)
