ABCB6 antibody, UMAT antibody, MTABC3 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSA00216W

$240USD

ID Tag

Rb1961-091212-WS

Immunogen

A synthetic peptide from aa region 400-500 of mouse ABCB6 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

ABCB6_MOUSE
ABCB6_RAT
ABCB6_HUMAN

Also known

ATP-binding cassette sub-family B member 6, mitochondrial, Mitochondrial ABC transporter 3, Mt-ABC transporter 3, P-glycoprotein-related protein, Ubiquitously-expressed mammalian ABC half transporter, MTABC3, PRP, UMAT

Target

FUNCTION: Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis.
Defects in ABCB6 are the cause of microphthalmia, isolated, with coloboma, type 7 (MCOPCB7).
Subcellular location: Cell membrane. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus
Tissue specificity: Widely expressed. High expression is detected in the retinal epithelium.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Krishnamurthy P.C, et al. Nature 443:586-589(2006)

Limitation

For research use only