ABCE1 antibody, Ribonuclease 4 inhibitor antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSA00213W

$240USD

ID Tag

Rb1958-091212-WS

Immunogen

A synthetic peptide from aa region 500-600 of mouse ABCE1 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

ABCE1_MOUSE
ABCE1_HUMAN
ABCE1_RAT

Also known

ATP-binding cassette sub-family E member 1, 2'-5'-oligoadenylate-binding protein, HuHP68, RNase L inhibitor, Ribonuclease 4 inhibitor, RNS4I, RLI, RNASEL1, RNASELI

Target

FUNCTION: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly.
Subcellular location: Cytoplasm. Mitochondrion. Note: Localized to clusters of virus formation at the plasma membrane.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Zimmerman C, et al. Nature 415:88-92(2002)

Limitation

For research use only

Code

OSA00213W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for ABCE1.

Spcs X-react.

Human, mouse. Other species not yet tested but expected to work in rat.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSA00213W