CRX antibody, CORD2 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSC00278W

$240USD

ID Tag

Rb1937-281012-WS

Immunogen

A synthetic peptide from aa region 250-300 of human CORD2 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

CORD2_HUMAN
CORD2_MOUSE
CORD2_RAT

Also known

Cone-rod homeobox protein, CRX

Target

FUNCTION: Binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors
Defects in CRX are the cause of Leber congenital amaurosis type 7 (LCA7).
Defects in CRX are the cause of cone-rod dystrophy type 2 (CORD2).
Defects in CRX are a cause of retinitis pigmentosa (RP)
SUBCELLULAR LOCATION: Nucleus
TISSUE SPECIFICITY: Retina

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Freund C.L, et al. Cell 91:543-553(1997)
2. Nichols L.L, et al. Hum. Mutat. 31:E1472-E1483(2010)

Limitation

For research use only

Code

OSC00278W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for CORD2.

Spcs X-react.

Human, mouse, rat. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSC00278W