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Code
OSS00357W
$240USD
ID Tag
Rb1935-281012-WS
Immunogen
A synthetic peptide from aa region 2-50 of human SLC29A3 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Equilibrative nucleoside transporter 3, Solute carrier family 29 member 3, ENT3
Target
FUNCTION: Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.
Defects in SLC29A3 are the cause of histiocytosis-lymphadenopathy plus syndrome (HLAS).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note: Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface.
Tissue specificity: Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart.
Defects in SLC29A3 are the cause of histiocytosis-lymphadenopathy plus syndrome (HLAS).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note: Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface.
Tissue specificity: Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Hyde R.J, et al. Mol. Membr. Biol. 18:53-63(2001)
2. Baldwin S.A, et al. J. Biol. Chem. 280:15880-15887(2005)
2. Baldwin S.A, et al. J. Biol. Chem. 280:15880-15887(2005)
Limitation
For research use only
- Click to download the Data Sheet
⚬ Products
Rabbit antibody to SLC29A3 (2-50)
