Rb1912-211012-WS

A synthetic peptide from aa region 300-350 of Drosophila melanogaster INDY conjugated to blue carrier protein was used as the antigen.

Transporter protein, drIndy

FUNCTION: Cation-independent electroneutral transporter (not associated with membrane depolarization) of a variety of tricarboxylic and dicarboxylic acid-cycle intermediates. There is also small, but detectable, transport of monocarboxylics. Transport is through the epithelium of the gut and across the plasma membranes of organs involved in intermediary metabolism and storage. Affinity for substrates is citrate > succinate > pyruvate. Fumarate, a-ketoglutarate, and glutarate are also transported, but not lactate. Transport mechanism that is not coupled to Na⁺, K⁺, or Cl^-. Function is shown in Xenopus oocytes and human retinal pigment epithelial (HRPE) cell lines.
The life-extending effect of mutations is likely caused by an alteration in energy balance caused by a decrease in transport function.
SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Note: Basolateral membrane of cells in the midgut.
Tissue specificity: In adults, abundantly expressed in the fat body, basolateral region of midgut cells and oenocytes. Low level expression is seen in the halteres, procardia, restricted regions of the esophagus and hindgut, base of the legs and in a subset of cells in the third segment of the antennae.

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Knauf F, et al. Proc. Natl. Acad. Sci. U.S.A. 99:14315-14319(2002)

For research use only

100 ul

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 500 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for INDY.

Drosophila melanogaster. Other species not yet tested.

Lyophilised

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet