|
|
Code
OSC00277W
$240USD
ID Tag
Rb1904-211012-WS
Immunogen
A synthetic peptide from aa region 400-500 of mouse CATSPER2 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
CTSR2, CatSper2
Target
Function: Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.
Defects in CATSPER2 are a cause of deafness-infertility syndrome (DIS). DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes.
Subcellular location: Cell projection ⺠cilium ⺠flagellum membrane; Multi-pass membrane protein
Tissue specificity: Testis-specific. Specifically present in the principal piece of sperm tail.
Defects in CATSPER2 are a cause of deafness-infertility syndrome (DIS). DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes.
Subcellular location: Cell projection ⺠cilium ⺠flagellum membrane; Multi-pass membrane protein
Tissue specificity: Testis-specific. Specifically present in the principal piece of sperm tail.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Quill T.A, et al. Proc. Natl. Acad. Sci. U.S.A. 98:12527-12531(2001)
2. Chung J.J, et al. Nat. Commun. 2:153-153(2011)
2. Chung J.J, et al. Nat. Commun. 2:153-153(2011)
Limitation
For research use only
Code
OSC00277W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for CATSPER2.
Spcs X-react.
Mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSC00277W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to CATSPER2
