Rb1894-201012-WS

A synthetic peptide from aa region 2-50 of human CLCN3 conjugated to an immunogenic carrier protein was used as the antigen.

CLCN3_HUMAN
CLCN3_MOUSE
CLCN3_RAT

Chloride channel protein 3, H(+)/Cl(-) exchange transporter 3, ClC-3, Chloride transporter ClC-3

FUNCTION: Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
Subcellular location: Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Cytoplasmic vesicle › secretory vesicle membrane. Note: Isoform 2 partially colocalized with isoform 1 but is mainly enriched in the Golgi.
Tissue specificity: Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Borsani G, et al. Genomics 27:131-141(1995)
2. Lamb F.S, et al. J. Mol. Cell. Cardiol. 31:657-666(1999)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for CLCN3.

Human, mouse, rat. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet