Rb1918-281012-WS

A synthetic peptide from aa region 100-200 of human SLC4A11 conjugated to an immunogenic carrier protein was used as the antigen.

Sodium bicarbonate transporter-like protein 11, Bicarbonate transporter-related protein 1, Sodium borate cotransporter 1, NaBC1, Solute carrier family 4 member 11, BTR1

Function: Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na⁺ and OH^-(H⁺) channel. In the presence of borate functions as an electrogenic Na⁺ coupled borate cotransporter.
Tissue specificity: Widely expressed. Highly expressed in kidney, testis, salivary gland, thyroid, trachea and corneal endothelium. Not detected in retina and lymphocytes.
Defects in SLC4A11 are the cause of corneal dystrophy and perceptive deafness (CDPD).
Defects in SLC4A11 are the cause of corneal endothelial dystrophy type 2 (CHED2).
Defects in SLC4A11 are the cause of corneal dystrophy Fuchs endothelial type 4 (FECD4).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Vithana E.N, et al. Hum. Mol. Genet. 17:656-666(2008)
2. Vilas G.L, et al. Hum. Mutat. 33:419-428(2012)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for SLC4A11.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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