Rb1801-260512-WS

A synthetic peptide from aa region of 10-100 of human KCNK18 (TRESK, KCNKI) conjugated to blue carrier protein was used as the antigen.

Potassium channel subfamily K member 18, Two-pore-domain potassium channel TRESK, KCNKI

Function: Outward rectifying potassium channel. Produces rapidly activating outward rectifier K⁺ currents. May function as background potassium channel that sets the resting membrane potential. Inhibited by arachidonic acid and other naturally occurring unsaturated free fatty acids. Channel activity is enhanced by high cytoplasmic calcium levels, due to activation of the protein phosphatase calcineurin. The volatile anestetic isoflurane enhances potassium currents.
Defects in KCNK18 are a cause of migraine with or without aura type 13 (MGR13).
Mutations in KCNK18 are a rare cause of migraine.
Tissue specificity: Detected in brain cortex, cerebellum, dorsal root ganglion, trigeminal ganglion neurons, spinal cord and testis.
Subcellular location: Membrane, Multi-pass membrane protein.

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Sano Y, et al. J. Biol. Chem. 278:27406-27412(2003).

For research use only

100 ul

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for KCNK18.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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- Click to download the Material Safety Data Sheet