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Code
OSP00167W
$260USD
ID Tag
Rb1807-260512-WS
Immunogen
A synthetic peptide from mouse PKD1 conjugated to blue carrier protein was used as the antigen.
Accession
Also known
Polycystin-1, Autosomal dominant polycystic kidney disease protein 1
Target
FUNCTION: Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling. May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell projection ⺠cilium.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell projection ⺠cilium.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Gluecksmann-Kuis M.A, et al. Cell 81:289-298(1995).
Limitation
For research use only
Code
OSP00167W
$260USD
Unit size
100 ul
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user.
Specificity
Specific for PKD1.
Spcs X-react.
Mouse. Other species not yet tested but expected to work i rat.
Format
Lyophilised
Reconstitution
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSP00167W
$260USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to PKD1
