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Code
OSG00085W
$240USD
ID Tag
Rb1742-020111-WS
Immunogen
A synthetic peptide from aa region 400-500 of human GABA(A) receptor subunit beta-2 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Gamma-aminobutyric acid receptor subunit beta-2, GABRB2
Target
FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
SUBCELLULAR LOCATION: Cell junction ⺠synapse ⺠postsynaptic cell membrane; Multi-pass membrane
Tissue specificity: Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
SUBCELLULAR LOCATION: Cell junction ⺠synapse ⺠postsynaptic cell membrane; Multi-pass membrane
Tissue specificity: Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Hadingham K.L, et al. Mol. Pharmacol. 44:1211-1218(1993)
2. McKinley D.D, et al. Brain Res. Mol. Brain Res. 28:175-179(1995)
3. Zhao C, et al. Mol. Psychiatry 11:1092-1105(2006)
2. McKinley D.D, et al. Brain Res. Mol. Brain Res. 28:175-179(1995)
3. Zhao C, et al. Mol. Psychiatry 11:1092-1105(2006)
Limitation
For research use only
Code
OSG00085W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for GABRB2.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSG00085W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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