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Code
OSG00084W
$240USD
ID Tag
Rb1741-020111-WS
Immunogen
A synthetic peptide from aa region 300-400 of human GABA(A) receptor subunit beta-3 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Gamma-aminobutyric acid receptor subunit beta-3, GABRB3
Target
FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Defects in GABRB3 are associated with chronic insomnia, a condition of inability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
Defects in GABRB3 are the cause of childhood absence epilepsy type 5 (ECA5).
SUBCELLULAR LOCATION: Cell junction ⺠synapse ⺠postsynaptic cell membrane; Multi-pass membrane
Defects in GABRB3 are associated with chronic insomnia, a condition of inability to initiate or maintain sleep. This may occur as a primary disorder or in association with another medical or psychiatric condition.
Defects in GABRB3 are the cause of childhood absence epilepsy type 5 (ECA5).
SUBCELLULAR LOCATION: Cell junction ⺠synapse ⺠postsynaptic cell membrane; Multi-pass membrane
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Wagstaff J, et al. Genomics 11:1071-1078(1991)
2. Kirkness E.F, et al. J. Biol. Chem. 268:4420-4428(1993)
3. Buhr A, et al. Hum. Genet. 111:154-160(2002)
2. Kirkness E.F, et al. J. Biol. Chem. 268:4420-4428(1993)
3. Buhr A, et al. Hum. Genet. 111:154-160(2002)
Limitation
For research use only
Code
OSG00084W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for GABRB3.
Spcs X-react.
Human. Other species not yet tested but expected to work in mouse and rat.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSG00084W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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