Rb1730-020111-WS

A synthetic peptide from 3d cytoplasmic region of human ATP10A conjugated to blue carrier protein was used as the antigen.

ATP10A_HUMAN
ATP10A_MOUSE
ATP10A_RAT

Probable phospholipid-transporting ATPase VA, ATPase class V type 10A, ATP10C, ATPVA, ATPVC

Involvement in disease: Defects in ATP10A are a cause of Angelman syndrome (AS); also known as 'happy puppet syndrome'. AS is characterized by features of severe motor and intellectual retardation, microcephaly, ataxia, frequent jerky limb movements and flapping of the arms and hands, hypotonia, hyperactivity, hypopigmentation, seizures, absence of speech, frequent smiling and episodes of paroxysmal laughter, and an unusual facies characterized by macrostomia, a large mandible and open-mouthed expression, a great propensity for protruding the tongue ('tongue thrusting'), and an occipital groove.
Subcellular location: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane. Note: Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not that of TMEM30B.
Tissue specificity: Widely expressed, with highest levels in kidney, followed by lung, brain, prostate, testis, ovary and small intestine.

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Meguro M, et al. Nat. Genet. 28:19-20(2001)

For research use only

100 ul

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for ATP10A.

Human, mouse, rat. Other species not yet tested.

Lyophilised

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet