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Code
OSH00039W
$240USD
ID Tag
Rb1724-020111-WS
Immunogen
A synthetic peptide from internal region of human internal region of Core histone macro-H2A.2 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Histone macroH2A2, mH2A2, H2AFY2
Target
FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note: Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note: Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1.Costanzi C, et al. J. Biol. Chem. 276:21776-21784(2001)
2. Zhang R, et al. Dev. Cell 8:19-30(2005)
2. Zhang R, et al. Dev. Cell 8:19-30(2005)
Limitation
For research use only
- Click to download the Data Sheet
⚬ Products
Rabbit antibody to Core histone macro-H2A.2
