CFTR antibody, ABCC7 antibody, Cystic fibrosis transmembrane conductance regulator antibody, Channel conductance controlling ATPase antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSC00244W

$240USD

ID Tag

Rb1682-021210-WS

Immunogen

A synthetic peptide from aa region 20-70 of mouse ABCC7 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and shares 95% with human sequence.

Accession

ABCC7_MOUSE
ABCC7_RAT
ABCC7_HUMAN

Also known

Cystic fibrosis transmembrane conductance regulator, Channel conductance-controlling ATPase, cAMP-dependent chloride channel, ATP-binding cassette transporter sub-family C member 7, CFTR

Target

FUNCTION: Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Defects in CFTR are the cause of congenital bilateral absence of the vas deferens (CBAVD). CBAVD is an important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
Subcellular location: Membrane, Multi-pass membrane protein.
Tissue specificity: Found on the surface of the epithelial cells that line the lungs and other organs.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Denamur E, et al. Hum. Mol. Genet. 3:1089-1094(1994)
2. Delaney S.J, et al. Nat. Genet. 4:426-431(1993)

Limitation

For research use only

Code

OSC00244W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for ABCC7.

Spcs X-react.

Mouse, rat. Other species not yet tested but expected to work in human.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSC00244W