Rb1633-211110-WS

A synthetic peptide from n-terminal region of human HOMER2 (Home2, Cupidin, Homer-2) conjugated to an immunogenic carrier protein was used as the antigen.

Home2, Homer protein homolog 2, Cupidin

FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with CENTG1. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses.
SUBUNIT: Isoform 1 and isoform 2 encode coiled-coil structures that mediate homo- and heteromultimerization.
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note: Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Xiao B, et al. Neuron 21:707-716(1998).
2. Soloviev M, et al. J. Mol. Biol. 295:1185-1200(2000).
3. Tu J.C, et al. Neuron 21:717-726(1998).
4. Barzik M, et al. J. Mol. Biol. 309:155-169(2001).
5. Kato A, et al. J. Biol. Chem. 273:23969-23975(1998).
6. Rong R, et a. Nat. Neurosci. 6:1153-1161(2003).

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for Homer2.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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