Rb1615-120910-WS

A synthetic peptide from c-terminal region of human Mitochondrial glutamate carrier 1 (SLC25A22) conjugated to an immunogenic carrier protein was used as the antigen.

SLC25A22_HUMAN
SLC25A22_MOUSE
SLC25A22_RAT

GC-1, Glutamate/H(+) symporter 1, Solute carrier family 25 member 22, SLC25A22, GC1

FUNCTION: Involved in the transport of glutamate across the inner mitochondrial membrane. Glutamate is cotransported with H⁺.
Defects in SLC25A22 are the cause of epileptic encephalopathy early infantile type 3 (EIEE3); also known as early myoclonic encephalopathy (EME) or neonatal epilepsy with suppression-burst pattern. Severe neonatal epilepsies with suppression-burst pattern are early-onset epileptic syndromes characterized by a typical EEG pattern. The suppression-burst pattern of the EEG is characterized by higher-voltage bursts of slow waves mixed with multifocal spikes alternating with isoelectric suppression phases. EME is characterized by a very early onset, erratic and fragmentary myoclonus, massive myoclonus, partial motor seizures and late tonic spasms. The prognosis of EME is poor, with no effective treatment, and children with the condition either die within 1 to 2 years after birth or survive in a persistent vegetative state. EME inheritance is autosomal recessive.
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein
Tissue specificity: Highly expressed in most tissues.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Fiermonte G, et al. J. Biol. Chem. 277:19289-19294(2002)
2. Molinari F, et al. Am. J. Hum. Genet. 76:334-339(2005)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for SLC25A22.

Human. Other species not yet tested but expected to work in rat and mouse.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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- Click to download the Material Safety Data Sheet