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Code
OSP00137W
$240USD
ID Tag
Rb656-060908-WS
Immunogen
A synthetic peptide from the cytoplasmic domain of chicken p75NTR (low affinity NGF receptor, p75, LNGFR, p75NTR) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, Low affinity neurotrophin receptor p75NTR, p75, LNGFR, p75NTR, RNNGFRR
Target
FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1. Interacts with ARMS and NTRK1. Can form a ternary complex with NTRK1 and ARMS and this complex is affected by the expression levels of ARMS. An increase in ARMS expression leads to a decreased association of NGFR and NTRK1. Interacts with LINGO1.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Radeke M.J, et al. Nature 325:593-597(1987).
2. Metsis M, et al. Gene 121:247-254(1992).
3. Kong H, et al. J. Neurosci. 21:176-185(2001).
4. Chang M.-S, et al. J. Neurosci. Res. 78:186-192(2004).
5. Vilar M, et al. EMBO J. 25:1219-1230(2006).
6. Liepinsh E, et al. EMBO J. 16:4999-5005(1997).
2. Metsis M, et al. Gene 121:247-254(1992).
3. Kong H, et al. J. Neurosci. 21:176-185(2001).
4. Chang M.-S, et al. J. Neurosci. Res. 78:186-192(2004).
5. Vilar M, et al. EMBO J. 25:1219-1230(2006).
6. Liepinsh E, et al. EMBO J. 16:4999-5005(1997).
Limitation
For research use only
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Code
OSP00137W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for p75NTR.
Spcs X-react.
Rat, mouse, human, chicken. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSP00137W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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