Rb1550-130810-WS

A synthetic peptide to the n-terminal region of human HER2 (CD340, ERBB2) conjugated to an immunogenic carrier protein was used as the antigen.

ERBB2, Receptor tyrosine-protein kinase erbB-2, Metastatic lymph node gene 19 protein, MLN 19, Proto-oncogene Neu, Proto-oncogene c-ErbB-2, Tyrosine kinase-type cell surface receptor HER2, p185erbB2, CD340

FUNCTION: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Binds to the 5'-TCAAATTC-3' sequence in the MT-CO2 promoter and activates its transcription.
Defects in ERBB2 are associated with gastric cancer; also known as hereditary familial diffuse gastric cancer (HDGC).
Defects in ERBB2 are involved in the development of glioma. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas.
Defects in ERBB2 are a cause of susceptibility to ovarian cancer (OC). Ovarian cancer common malignancy originating from ovarian tissue. Although many histologic types of ovarian neoplasms have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
Defects in ERBB2 are associated with lung cancer; also called adenocarcinoma of lung.
Subcellular location: Cell membrane; Single-pass type I membrane protein. Cytoplasm › perinuclear region. Nucleus ssed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Yamamoto T, et al. Nature 319:230-234(1986)
2. Coussens L, et al. Science 230:1132-1139(1985)
3. King C.R, et al. Science 229:974-976(1985)
4. Swiercz J.M, et al. J. Cell Biol. 165:869-880(2004)
5. Cho H.-S, et al. Nature 421:756-760(2003)

For research use only

200 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for HER2.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 200 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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