Rb1549-130810-WS

A synthetic peptide from n-terminal region of human LIN7 (A, B, C) conjugated to an immunogenic carrier protein was used as the antigen.

LIN7A_HUMAN
LIN7B_MOUSE
LIN7C_RAT

LIN7A, Protein lin-7 homolog A, Lin-7A, Mammalian lin-seven protein 1, MALS-1, Tax interaction protein 33, TIP-33, Vertebrate lin-7 homolog 1, Veli-1, MALS1, VELI1. LIN7B, Protein lin-7 homolog B, Lin-7B, Mammalian lin-seven protein 2, MALS2, VELI1. LIN7C, Protein lin-7 homolog C, Lin-7C, Mammalian lin-seven protein 3, MALS3, VELI3.

FUNCTION: LIN7A: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.
Subcellular location: Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Cell junction › synapse › postsynaptic cell membrane › postsynaptic density; Peripheral membrane protein. Cell junction › tight junction. Cell junction › synapse › synaptosome. Note: Enriched in synaptosomes and at epithelial cell-cell junctions. Mainly basolateral in renal epithelial cells.
Tissue specificity: Expressed in brain, testis, kidney, placenta and liver.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Butz S, et al. Cell 94:773-782(1998)
2. Jo K, et al. J. Neurosci. 19:4189-4199(1999)
3. Rousset R, et al. Oncogene 16:643-654(1998)
4. Tseng T.-C, et al. Biochim. Biophys. Acta 1518:249-259(2001)
5. Bohl J, et al. J. Biol. Chem. 282:9392-9400(2007)

For research use only

	Code Product Name OSL00017W Rabbit antibody to LIN7

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for LIN7A, B, C.

Mouse, rat, human. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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- Click to download the Material Safety Data Sheet