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Code
OSS00263W
$240USD
ID Tag
Rb1537-130810-WS
Immunogen
A synthetic peptide from n-terminal region of human Zinc transporter 8 (SLC30A8, ZNT8) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
ZnT-8, Solute carrier family 30 member 8, SLC30A8, ZNT8
Target
FUNCTION: Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta-cells.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle ⺠secretory vesicle membrane; Multi-pass membrane protein Probable. Note: Associated with insulin and glucagon secretory granules
TISSUE SPECIFICITY: In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle ⺠secretory vesicle membrane; Multi-pass membrane protein Probable. Note: Associated with insulin and glucagon secretory granules
TISSUE SPECIFICITY: In the endocrine pancreas, expressed in insulin-producing beta cells. Expressed at relatively high levels in subcutaneous fat tissue from lean persons; much lower levels in visceral fat, whether from lean or obese individuals, and in subcutaneous fat tissue from obese individuals. Expressed in peripheral blood mononuclear cells, including T-cells and B-cells, with great variation among individuals ranging from negative to strongly positive.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Chimienti F, et al. Diabetes 53:2330-2337(2004)
2. Chimienti F, et al. BioMetals 18:313-317(2005)
3. Smidt K, et al. Mol. Cell. Endocrinol. 264:68-73(2007)
2. Chimienti F, et al. BioMetals 18:313-317(2005)
3. Smidt K, et al. Mol. Cell. Endocrinol. 264:68-73(2007)
Limitation
For research use only
Code
OSS00263W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for SLC30A8.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSS00263W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Rabbit antibody to SLC30A8
