Code
OSS00252W
$240USD
ID Tag
Rb1558-290810-WS
Immunogen
A synthetic peptide from n-terminal region of mouse SLC38A1 (Solute carrier family 38 member 1) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Sodium-coupled neutral amino acid transporter 1, Amino acid transporter A1, N-system amino acid transporter 2, Solute carrier family 38 member 1, System A amino acid transporter 1, System N amino acid transporter 1, ATA1, NAT2, SAT1, SNAT1
Target
FUNCTION: Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of glutamine and sodium ions with a stoichiometry of 1:1. May also transport small zwitterionic and aliphatic amino acids with a lower affinity. May supply glutamatergic and GABAergic neurons with glutamine which is required for the synthesis of the neurotransmitters glutamate and GABA.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Note: Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain.
Tissue specificity: Expressed in the cerebral cortex by pyramidal and GABAergic neurons, astrocytes and other non-neuronal cells (at protein level). Expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Wang H, et al. Biochem. Biophys. Res. Commun. 273:1175-1179(2000)
2. Nelson D.M, et al. Am. J. Physiol. 284:C310-C315(2003)
3. Desforges M, et al. Am. J. Physiol. 290:C305-C312(2006)
Limitation
For research use only
Code
OSS00252W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (confirmed by recombinant protein). A dilution of 1: 200 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for SLC38A1.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.